Isolated Limb Perfusion

Experience with isolated limb perfusion

Isolated limb perfusion with melphalan for melanoma.

Isolated limb perfusion with melphalan is a well-established and effective treatment for inoperable melanoma metastases of the extremities, with an overall response rate of 80% and a complete response rate of 54%. The surgical technique is complex and serious morbidity can occur, but with attention to detail major side effects can be kept to a minimum. This article reviews the technique, result...

Isolated limb perfusion: a literature review.

Through patient education, biological research, and technological advances, the rate of many cancers in the United States of America is declining. However, the incidence of melanoma is rising steadily, as are the efforts and resources allocated to its treatment. Isolated limb perfusion, ILP, is a standard of care for treating recurrent malignant melanoma confined to a limb. Although an extracor...

Hyperthermic isolated limb perfusion for extremity sarcomas.

BACKGROUND The treatment options available for extremity sarcomas are amputation or limb-sparing surgery with radiation, which may incur significant morbidity and body disfigurement. Hyperthermic isolated limb perfusion (HILP) may be an attractive option in extremity sarcomas for unresectable lesions to preserve limb function and maintain quality of life. METHODS We report the outcomes of 5 p...

Isolated limb infusion for melanoma: a simple alternative to isolated limb perfusion.

OBJECTIVE To describe initial experience with the new technique of isolated limb infusion (ILI) for in-transit melanoma. DESIGN A prospective case series. SETTING The major tertiary care oncology centre for the state of Victoria, Australia. PATIENTS Nine patients having for extensive in-transit limb melanoma INTERVENTIONS All patients received ILI (13 treatments). OUTCOME MEASURES Pat...